Econazole nitrate topical spray is a novel dosage form formulated for the treatment of superficial fungal infections. Study was designed to formulate and evaluate the performance of econazole nitrate spray formulations by varying the concentrations of different constituents of the spray. Twelve formulations of econazole nitrate topical spray were prepared using 22 full factorial design, where components of formulation such as penetration enhancer (X1) and co-solvent (X2) were selected as independent variables and % drug release (Y1) and % drug retention in skin (Y2) were selected as dependent variables. All the formulations of spray were pressurized with LPG propellant and evaluated for delivery rate, delivery amount, pressure, minimum fill, flammability, density, pH, spray pattern, particle size, unit content per spray, spray angle, leakage test and ex vivo penetration studies. Effect of independent variables on dependent variables was investigated.Optimised formulation was finally compared for ex-vivo release and retention study with marketed preparation. Short-term stability study of optimized formulation demonstrated insignificant changes in performance characteristics.
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